![]() The lack of correlation between cBZR binding and neuronal density implies that atrophy with neuron loss is not the sole determinant of reduced cBZR binding in patients with mTLE and hippocampal sclerosis. Pay your Cunningham Pathology bill online with doxo, Pay with a credit card, debit card, or direct from your bank account. ![]() I am able to assist in the diagnosis of many patients and help clinicians find answers to. After correction for partial-volume effect we found a mean 38% reduction of FMZ-Vd in the sclerosed hippocampus, over and above the reduction of HCV.Ĭorrection for partial-volume effect allows absolute quantitation of FMZ-PET and increases its sensitivity for detecting abnormalities in TLE due to HS. Pathology is a fascinating unique field that not many speak about. There was no correlation between corrected absolute FMZ-Vd and HCV or neuronal cell density. After partial-volume effects correction all 17 patients (100%) showed both significant unilateral reduction of absolute FMZ-Vd and abnormal FMZ-AI. ![]() Its testing services include immunocytochemistry, breast pathology, cytopathology, dermatopathology, hematopathology, ophthalmologic pathology and neuropathology. Absolute FMZ-Vd and asymmetry indices (FMZ-AI) were compared before and after partial-volume effect correction with MRI-determined hippocampal volumes (HCV), hippocampal T2 measurements, and, if available, neuronal cell densities.Ĭompared with 15 age-matched healthy volunteers, significant reductions of absolute hippocampal FMZ-Vd were found before correction for partial-volume effects in 11 of 17 patients (65%) and only abnormal FMZ-AI in the other six patients. Cunningham Pathology is a full-service provider of anatomic pathology services and has been serving the southern United States for more than 50 years. Quantitative neuropathology was performed with assessment of neuron density in 14 of the 17 patients. We determined hippocampal volume loss and reduction in cBZR binding using an MRI-based method for partial-volume effect correction of 11C-FMZ volume of distribution (FMZ-Vd) in 17 patients with refractory mTLE and an MRI diagnosis of HS that was subsequently histologically verified in all cases. ![]() The limited spatial resolution of PET, however, results in partial-volume averaging that affects quantitative analysis of cBZR density. Cunningham is the Director of the Ontario Forensic Pathology Service (OFPS) Molecular Autopsy Program and oversees operational completion of over 6,200 autopsies per year at the Provincial Forensic Pathology Unit in Toronto.Using statistical parametric mapping and 11C-flumazenil (FMZ) PET we have previously shown reduction of central benzodiazepine receptor (cBZR) binding restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) due to hippocampal sclerosis (HS). He has spent multiple years training Forensic Pathology and Cardiovascular Pathology fellows and has taught medical students, undergraduate students and postgraduate pathology residents for many years. Cunningham is an Assistant Professor within Laboratory Medicine and Pathobiology at the University of Toronto, has been Medical Director at the Toronto and Kingston Forensic Pathology Units and is currently the Deputy Chief Forensic Pathologist. Hannah is an integrative and functional Naturopath with a deep understanding of nutritional biochemistry and routine pathology testing who works with her. His preparation in Anatomical Pathology (with dedicated training in Cardiovascular and in Forensic Pathology) was completed at the University of Toronto (2009).ĭr. Cunningham completed his PhD at the Ohio State University in Biochemistry (2000) and his Doctor of Medicine degree at the University of Ottawa (2004).
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